Chemistry Heterocyclic Building Blocks Pyrazoles Pyrazolo[1,5-A]Pyrazine

Pyrazolo[1,5-A]Pyrazine

Substitution Reactions: Pyrazolo[1,5-a]pyrazine can undergo various substitution reactions. For example, the nitrogen atoms in the pyrazine rings can be substituted with different groups, such as alkyl, aryl, or acyl groups. These substitutions can be achieved through reactions like nucleophilic substitution or electrophilic substitution. Oxidation and Reduction Reactions: Pyrazolo[1,5-a]pyrazine can undergo oxidation or reduction reactions depending on the reaction conditions. For instance, it can be oxidized to form pyrazolo[1,5-a]pyrazine-3,6-dicarboxylic acid or reduced to form pyrazolo[1,5-a]pyrazine-3,6-diamine. Cyclization Reactions: Pyrazolo[1,5-a]pyrazine can participate in cyclization reactions to form more complex ring structures. This may involve the addition of reagents to specific positions on the molecule, resulting in the formation of fused or bridged ring systems. Cross-Coupling Reactions: Pyrazolo[1,5-a]pyrazine can be used as a substrate in cross-coupling reactions, such as Suzuki-Miyaura or Heck reactions, to attach various aryl or alkyl groups to its structure. Functional Group Transformations: The functional groups on pyrazolo[1,5-a]pyrazine, if present, can undergo various transformations. For example, you can perform reactions like acylation, alkylation, or halogenation to modify the functional groups. Ring-Opening Reactions: Depending on the reaction conditions and the substituents present, ring-opening reactions may occur to produce open-chain compounds. This can be achieved under specific reaction conditions. Heterocycle Formation: Pyrazolo[1,5-a]pyrazine can participate in heterocycle formation reactions with other heterocyclic compounds, leading to the synthesis of more complex heterocyclic structures.

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Framework+−

(1-Methyl-1H-Pyrazol-3-Yl)Methanol (1-Phenyl-1H-Pyrazol-4-Yl)Boronic Acid 1,3-Dimethyl-1H-Pyrazole 1,3-Diphenyl-1H-Pyrazole 1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazole 1,5-Diphenyl-1H-Pyrazole 1-(2-Chlorophenyl)-1H-Pyrazole 1-(3-Chlorophenyl)-1H-Pyrazole 1-(4-Methoxybenzyl)-1H-Pyrazole 1-(Azetidin-3-Yl)-1H-Pyrazole 1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazole 1-(Tetrahydro-2H-Pyran-4-Yl)-1H-Pyrazole 1-Benzyl-1H-Pyrazolo[3,4-B]Pyridine 1-Benzyl-4-Bromo-1H-Pyrazole 1-Benzyl-4-Iodo-1H-Pyrazole 1-Cyclopentyl-1H-Pyrazole 1-Cyclopropyl-1H-Pyrazole 1-Methyl-1H-Pyrazol-3-Amine 1-Methyl-3-Phenyl-1H-Pyrazole 1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole 1-Methyl-5-Phenyl-1H-Pyrazole 1-Phenyl-1H-Pyrazol-3-Amine 1-Phenyl-1H-Pyrazol-3-Ol 1-Phenyl-1H-Pyrazol-5-Amine 1-Phenyl-1H-Pyrazole-3-Carboxylic Acid 1-Phenyl-1H-Pyrazole-4-Carbaldehyde 1-Phenyl-1H-Pyrazole-4-Carbonitrile 1-Phenyl-1H-Pyrazole-4-Carboxylic Acid 1-Phenyl-1H-Pyrazole-5-Carboxylic Acid 1-Phenyl-3-(Trifluoromethyl)-1H-Pyrazole 1-Trityl-1H-Pyrazole 1H-Pyrazol-4-Amine 1H-Pyrazol-4-Ol 1H-Pyrazol-5-Amine 1H-Pyrazole-4-Carbaldehyde 1H-Pyrazole-4-Carbonitrile 1H-Pyrazole-4-Carboxylic Acid 1H-Pyrazole-4-Sulfonyl Chloride 1H-Pyrazole-5-Carboxamide 1H-Pyrazole-5-Carboxylic Acid 1H-Pyrazolo[3,4-B]Pyrazine 1H-Pyrazolo[3,4-B]Pyridin-5-Amine 1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine 1H-Pyrazolo[4,3-D]Pyrimidine 2,3-Dihydropyrazolo[5,1-B]Oxazole 2,4-Dihydro-3H-Pyrazol-3-One 2,6-Di(1H-Pyrazol-1-Yl)Pyridine 2-(1H-Pyrazol-1-Yl)Pyridine 2-(1H-Pyrazol-1-Yl)Pyrimidine 2-(1H-Pyrazol-3-Yl)Pyridine 2-Phenyl-2,4-Dihydro-3H-Pyrazol-3-One 3-(Tert-Butyl)-1-Phenyl-1H-Pyrazole 3-Bromo-1-Methyl-1H-Pyrazole 3-Bromopyrazolo[1,5-A]Pyridine 3-Bromopyrazolo[1,5-A]Pyrimidine 3-Chloro-1-Methyl-1H-Pyrazole 3-Cyclopropyl-1H-Pyrazole 3-Iodo-1-Methyl-1H-Pyrazole 3-Iodo-1H-Pyrazolo[3,4-B]Pyridine 3-Methyl-1-Phenyl-1H-Pyrazole 3-Phenyl-1H-Pyrazol-5-Amine 4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine 4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridine 4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrazine 4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyridine 4-(1H-Pyrazol-1-Yl)Benzoic Acid 4-(1H-Pyrazol-1-Yl)Piperidine 4-Bromo-1-Methyl-1H-Pyrazole 4-Bromo-1-Phenyl-1H-Pyrazole 4-Bromo-1H-Pyrazolo[3,4-B]Pyridine 4-Bromopyrazolo[1,5-A]Pyridine 4-Chloro-1H-Pyrazole 4-Chloro-1H-Pyrazolo[3,4-B]Pyridine 4-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine 4-Iodo-1H-Pyrazole 4-Methyl-1-Phenyl-1H-Pyrazole 4-Methyl-1H-Pyrazole 4-Nitro-1H-Pyrazole 4-Phenyl-1H-Pyrazole 5,6-Dihydro-4H-Pyrrolo[1,2-B]Pyrazole 5-(Difluoromethyl)-1H-Pyrazole 5-Bromo-1H-Pyrazole 5-Bromo-1H-Pyrazolo[3,4-B]Pyridine 5-Bromo-1H-Pyrazolo[3,4-C]Pyridine 5-Chloro-1H-Pyrazole 5-Chloro-1H-Pyrazolo[3,4-B]Pyridine 5-Chloropyrazolo[1,5-A]Pyrimidine 5-Cyclopropyl-1H-Pyrazole 5-Iodo-1H-Pyrazole 5-Nitro-1H-Pyrazole 5-Nitro-1H-Pyrazolo[3,4-B]Pyridine 5-Phenyl-1H-Pyrazole-3-Carboxylic Acid 6,7-Dihydro-5H-Pyrazolo[5,1-B][1,3]Oxazine 6-Bromopyrazolo[1,5-A]Pyridine 6-Bromopyrazolo[1,5-A]Pyrimidine 6-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine 7-Chloropyrazolo[1,5-A]Pyrimidine Ethyl 1-Phenyl-1H-Pyrazole-3-Carboxylate Ethyl 1-Phenyl-1H-Pyrazole-4-Carboxylate Ethyl 1H-Pyrazole-4-Carboxylate Ethyl Pyrazolo[1,5-A]Pyridine-3-Carboxylate Ethyl Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate Methyl 1H-Pyrazole-4-Carboxylate Methyl 1H-Pyrazolo[3,4-B]Pyridine-5-Carboxylate Methyl Pyrazolo[1,5-A]Pyridine-3-Carboxylate Pyrazolo[1,5-A]Pyrazine Pyrazolo[1,5-A]Pyridine-2-Carboxylic Acid Pyrazolo[1,5-A]Pyridine-3-Carboxylic Acid Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid Tert-Butyl 1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylate Tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole-1-Carboxylate

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Amino-Pyrazole-Carboxylate Amino-Pyrazolopyridine Aminopyrazolo Benzylpyrazol-Amide Bipyrazole Bromo-Methyl-Pyrazole Bromo-Pyrazol-Amide Bromo-Pyrazole-Carboxylate Bromo-Pyrazolopyridine Bromo-Pyrazolopyrimidine Bromo-Trifluoromethyl-Pyrazole Bromopyrazolo Chloro-Methyl-Pyrazole Chloro-Pyrazolamide Chloro-Pyrazole Chloro-Pyrazole-Carboxylate Chloro-Pyrazolopyridine Chloro-Pyrazolopyrimidine Chloropyrazolo Dichloropyrazolo Difluoromethyl-Pyrazole Difluoromethyl-Pyrazole-Carboxylate Dihydropyrazolo Dimethyl-Pyrazol-Amide Dimethyl-Pyrazole-Carboxylate Dimethyl-Pyrazole-Carboxylic Acid Dimethylpyrazole Dimethylpyrazolo Dioxaborolan-Pyrazole Ethyl-Pyrazol-Amide Ethylpyrazole Fluoropyrazolo Hydroxy-Pyrazole Hydroxy-Pyrazolopyrimidine Hydroxypyrazolo Iodo-Methyl-Pyrazole Iodo-Pyrazole-Carboxylate Iodopyrazolo Isopropyl-Pyrazol-Amide Methoxy-Pyrazolo-Pyridine Methoxypyrazolo Methy-Pyrazolooxazine Methyl-Hydrox-Ypyrazole Methyl-Nitro-Pyrazole Methyl-Pyrazol-One Methyl-Pyrazole-Carboxylic Acid Methyl-Pyrazole-Carboxylic-Acid Methyl-Pyrazolone Methyl-Pyrazolopyridine Methylpyrazole Methylpyrazolo Nitro-Pyrazole-Carboxylate Phenyl-Pyrazol-Amide Phenyl-Pyrazole-Carboxylate Phenyl-Pyrazolidine Phenylpyrazole Pyrazo-Morpholine Pyrazol-Amine Pyrazol-Boronic Acid Pyrazol-Methanol Pyrazol-One Pyrazol-Piperazine Pyrazol-Pyridine Pyrazole-Carbonitrile Pyrazole-Carboxylate Pyrazole-Carboxylic Acid Pyrazole-Ethanol Pyrazole-Hydrochloride Pyrazole-Methamine Pyrazole-Phenyl-Boronic-Acid Pyrazole-Piperidine Pyrazolo-Pyrimidine Pyrazolooxazine Pyrazolopyrazine Pyrazolopyridin-Ol Pyrazolopyridin-One Pyrazolopyridine Pyrazolopyridine-Carbonitrile Pyrazolopyridine-Carboxylate Pyrazolopyridine-Carboxylic Acid Pyrazolopyridine-Carboxylic-Acid Pyrazolopyridine-Methanol Pyrazolopyrimid-One Pyrazolopyrimidine Pyrazolotriazine Pyridine-Pyrazole Pyrimidine-Pyrazole Pyrrolopyrazole Tetrahydropyran-Pyrazole Tetrahydropyranopyrazole Tetrahydropyrazolo Trifluoromethyl-Phenyl-Pyrazol Trifluoromethyl-Pyrazol-Amide Trifluoromethyl-Pyrazole Trifluoromethyl-Pyrazolone

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Aliphatic Heterocycles Aromatic Heterocycles Azetidines Furans Guanidines Imidazoles Indazoles Indoles Other Aliphatic Heterocycles Other Aromatic Heterocycles Oxetanes Piperazines Piperidines Pyrazines Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Quinolines Tetrahydrofurans Tetrahydropyrans Thiophenes

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Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amines Aryls Benzyl Bromides Benzyl Chlorides Bromides Carboxylic Acids Chiral Building Blocks Chlorides Difluoromethyls Esters Ethers Fluorinated Building Blocks Hydrazones Iodides Ketones Nitriles Nitroes Oximes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfonic Acids Sulfonyl Chlorides Trifluoromethyls Ureas

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    1-(Pyrazolo[1,5-a]pyrazin-3-yl)ethan-1-one

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    Pyrazolo[1,5-a]pyrazine-3-carboxylic acid

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    4-Chloro-2-(trifluoromethyl)pyrazolo[1,5-a]pyrazine

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    2-(Trifluoromethyl)pyrazolo[1,5-a]pyrazin-4-ol

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    2-(Trifluoromethyl)pyrazolo[1,5-a]pyrazin-4-ol

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